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  • Total Questions: 200
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MRCPUK SEND Exam Syllabus Topics:

SectionObjectives
Calcium, Bone and Metabolic Disease- Calcium and vitamin D disorders
- Osteoporosis and metabolic bone disease
Neuroendocrine Tumours and Multiple Endocrine Neoplasia- Carcinoid and pancreatic NETs
- MEN syndromes
Reproductive Endocrinology- Polycystic ovary syndrome (PCOS)
- Hypogonadism and infertility
Endocrine Emergencies- Diabetic ketoacidosis and hyperosmolar states
- Thyroid and adrenal crisis
Adrenal Disorders- Cushing syndrome
- Addison disease and adrenal insufficiency
Diabetes Mellitus- Type 1 and Type 2 diabetes management
- Diabetic complications and emergencies
Thyroid Disease- Hyperthyroidism and hypothyroidism
- Thyroid nodules and cancer
Pituitary and Hypothalamic Disorders- Pituitary adenomas and hypopituitarism
- Diabetes insipidus and SIADH
Metabolic Disorders- Lipid disorders
- Obesity management

MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:

1. A 42-year-old woman, with type 1 diabetes mellitus of 22 years' duration, attended for annual review. She was using biphasic insulin twice daily and taking aspirin 75 mg, simvastatin 40 mg and ramipril 10 mg daily.
On examination, her blood pressure was 164/87 mmHg.
Investigations:
serum potassium5.9 mmol/L (3.5-4.9)
serum creatinine197 umol/L (60-110)
estimated glomerular filtration rate (MDRD)26 mL/min/1.73 m2 (>60)
haemoglobin A1c72 mmol/mol (20-42)
urinary albumin:creatinine ratio27.0 mg/mmol (<3.5)
urine culturenegative
What is the most important next step in management?

A) check bicarbonate
B) change to intensive insulin regimen
C) add aliskiren
D) refer to a nephrologist
E) add furosemide


2. A 52-year-old man had been found to have type 1 diabetes mellitus at the age of 25. He had developed retinopathy at the age of 31 and a painless foot ulcer at the age of 40. His renal function had subsequently deteriorated.
On examination, urinalysis showed protein 1+, glucose 2+.
What is the most likely diagnosis?

A) nodular glomerulosclerosis
B) minimal change glomerulonephritis
C) tubulointerstitial nephritis
D) focal segmental glomerulosclerosis
E) membranoproliferative glomerulonephritis


3. A 32-year-old woman presented at 34 weeks of pregnancy, after an episode of vaginal bleeding. Gestational diabetes had been diagnosed at 28 weeks and insulin was started at 29 weeks. Her pre-pregnancy body mass index was 32 kg/m2 (18-25) and there was no family history of diabetes. She was treated with betamethasone 12 mg over 2 days. She was taking 60 units of insulin subcutaneously daily (40 units prandial in three divided doses, and 20 units intermediate-acting insulin), which had been unchanged for 3 weeks.
On examination, she was apyrexial, her pulse was 96 beats per minute and her blood pressure was 124/74 mmHg. Urinalysis showed blood 1+, protein 1+, glucose 2+, ketones 3+.
Investigations:
serum sodium134 mmol/L (137-144)
serum potassium3.8 mmol/L (3.5-4.9)
serum chloride105 mmol/L (95-107) serum urea5.0 mmol/L (2.5-7.0) serum creatinine90 umol/L (60-110) random plasma glucose7.2 mmol/L
What is the most appropriate next step in management?

A) measure venous bicarbonate
B) continue to monitor blood glucose in hospital
C) increase subcutaneous insulin doses by 2-4 units
D) start intravenous insulin
E) discharge and monitor blood glucose at home


4. A 64-year-old man presented with palpitations, fatigue and malaise. Two months previously, he had sustained an acute myocardial infarction complicated by ventricular tachycardia and cardiac arrest, and had been discharged taking amiodarone 200 mg daily.
On examination, he appeared well, his pulse was 90 beats per minute and regular, and he
had mild tremor of his hands but no other abnormal signs.
Investigations:
serum thyroid-stimulating hormone6.2 mU/L (0.4-5.0)
serum free T418.2 pmol/L (10.0-22.0)
serum free T34.8 pmol/L (3.0-7.0)
What is the most appropriate next step in management?

A) repeat thyroid function tests in 12 months
B) start levothyroxine
C) repeat thyroid function tests in 2 months
D) isotope scan of thyroid
E) discontinue amiodarone


5. A 30-year-old man was reviewed in the diabetes clinic. He had type 1 diabetes mellitus of 6 months' duration, treated with subcutaneous insulin in a basal bolus regimen (short-acting insulin three times daily; long-acting insulin once daily).
Investigations:
haemoglobin A1c52 mmol/mol (20-42)
At what arterialised venous blood glucose threshold would a patient typically expect to develop neuroglycopenic symptoms?

A) 3.1-3.4 mmol/L
B) <2.3 mmol/L
C) 3.5-3.9 mmol/L
D) 2.3-2.6 mmol/L
E) 2.7-3.0 mmol/L


Solutions:

Question # 1
Answer: D
Question # 2
Answer: A
Question # 3
Answer: A
Question # 4
Answer: C
Question # 5
Answer: E

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